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PEA May Help With Other Types Of Pain. This supplement is found in EVERY healthy cell in your body. Your email address will not be published. VERY happy with this supplement! Research indicates it may be vital to supporting the body's natural pain response. It shows promise as a painkiller and anti-inflammatory, though large-scale safety and efficacy data are still lacking. or 180ct. There are over 500 clinical studies on PEA since 1957, most are related to neuropathic pain and mast cells (inflammation) activation. All of our content is written by scientists and people with a strong science background. In four additional studies, PEA lowered the chances of catching a cold and the severity of symptoms. PEA also reduces high blood pressure in rats and prevents kidney damage by lowering inflammatory substances. Palmitoylethanolamide (PEA) belong to endocannabinoid family, a group of fatty acid amides. Palmitoylethanolamide (PEA) is now available in 300mg Caps in Australia. It can be found in many different tissues including glia, neurons, retina, white blood cells, mast cells and adipocytes. However, PEA itself is a plant, and PEA protein is also applied in bodybuilding supplements as a vegetarian source of protein content. Micronized PEA supplements were used in most studies, some scientists considering them superior to other forms. Our science team is put through the strictest vetting process in the health industry and we often reject applicants who have written articles for many of the largest health websites that are deemed trustworthy. Compared to conventional therapy alone, PEA did not reduce neuropathic pain, spasticity, or insomnia [27]. Long-term PEA supplementation has not been linked to adverse effects in small-scale studies. Researchers hypothesize that the best way to get the benefits of PEA are standardized supplements, or alternatively, PEA-rich foods. We do not aim to diagnose, treat, cure or prevent any illness or disease. However, more research is needed to determine PEA’s exact mechanism and long-term safety. Palmitoylethanolamide (PEA) – backed by more than 300+ medical studies, has been shown to be or assist with: Natural pain reliever* Natural anti-inflammatory* Neuroprotective at the cellular level* Muscle recovery and muscle pain* Immune system support* Our website services, content, and products are for informational purposes only. PEA was used in doses of 300 mg to 1.8 g/day in clinical studies. As a kid, he suffered from inflammation, brain fog, fatigue, digestive problems, anxiety, depression, and other issues that were poorly understood in both conventional and alternative medicine. As scientists became excited about PEA’s ability to relieve pain and nerve damage, its effects on the immune system were almost forgotten. The effects were noticeable after 30 days and further improved over another month of supplementation [15]. However, some scientists say that simply increasing your intake of palmitic acid or other dietary fats will not affect PEA production in the body. The benefits of PEA for neuropathic pain are less clear due to insuffucient reliable evidence to date. Their hypothesis remains unproven, though [4]. In the brain, our natural cannabinoids play diverse roles in behavior, cognition, mood, and seizure risk, among others. Learn how your comment data is processed. PEA can also activate other receptors that boost cannabinoid activity (TRPV1). Ana has many years of experience in clinical research and health advising. She is a strong advocate of integrating scientific knowledge and holistic medicine. Long-term PEA given at the highest achievable doses to animals (1 g/kg of body weight) wasn’t toxic. Impaired natural cannabinoids may also play a role in epilepsy. is a clickable link to peer-reviewed scientific studies. The studies listed below should not be interpreted as supportive of any health benefit. You will find some of those studies below. Product includes one (1) 60ct. Clinical studies are needed to confirm these findings [16, 17]. In animal and cell-based studies, PEA improved eczema and skin allergies by lowering mast cell activation and blocking the release of histamine [2]. You’ll ideally be able to balance your cannabinoids before they cause any problems. This site uses Akismet to reduce spam. Solid evidence shows that PEA may reduce complex pain, but its impact on neuropathic pain is less clear. PEA combined with luteolin was also used in clinical trials. PEA has always been present in the food supply and is marketed as a dietary supplement. Palmitoylethanolamide, or PEA, is produced in the body naturally to combat pain and inflammation. It is very common in people who have type 2 diabetes, but can equally occur in those with various genetic conditions or after trauma. PEA may be beneficial for neurodegenerative diseases and stroke because it seems to help brain cells survive and lower inflammation. PEA (1,200 mg/day) reduced the duration of the cold and symptoms such as fever, headaches, and sore throat in a study of about 900 young soldiers. If you’re on a meat-heavy diet or are prone to food sensitivities, PEA supplements are a safer and more effective choice. Don’t get them wrong. This fatty acid is known as a peripherally-acting pain reliever. Mice with chronic gut inflammation have low PEA levels, while PEA supplements normalized bowel movement and prevented damage to the gut lining [2, 30]. It may only takes two weeks to achieve pain relief. People respond differently to diets and supplements because everyone has unique DNA. In dogs with eczema, PEA helped soothe symptoms by reducing skin inflammation and itching. This increases the levels of calming anandamide in your body, helping to combat pain and increase relaxation. 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